WYBRANE KOMUNIKATY

2011
  1. Polewska J, Skwarska A, Augustin E, Konopa J. Autophagy mediates imidazoacridnone C-1311-induced senesncence in human non-small lung cancer cells. FEBS J, 278, Suppl.1, p. 228-229, 2011.
  2. Pawłowska M, Augustin E, Wolf C.R, Mazerska Z. Different expression level of CYP3A4 isoenzyme modulate cellular response of CHO cells following treatment with the CYP3A4 inhibitor, C-1311 compound. Acta Biochim. Polonica, 58, Suppl.2, p. 207, 2011.
  3. Niemira M, Brillowska-Dąbrowska A, Konopa J, Mazerska Z. The antitumor derivatives, C-1305 and C-1748, were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells. FEBS J, 278, Suppl.1, p. 184, 2011.
  4. Niemira M, Mazerska Z. Selective effects of the antitumor derivatives, C-1305 and C-1748, on the protein levels and gene expression of CYP3A4 and MDR1 in HepG2 cells. Acta Biochim. Polonica, 58, Suppl.2, p. 82, 2011.
  5. Fedejko-Kap B, Potęga A, Mazerska Z. Reactive metabolites of acridinone antitumor agents, C-1305 and C-1311, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzyme inactivation. FEBS J, 278, Suppl.1, p. 6, 2011.
  6. Fedejko-Kap B, Bratton S.M, Finel M, Mazerska Z, Radominska-Pandya A. The role of intestine and liver in imidazo- and triazoloacridinone antitumor agents, C-1311 and C-1305, glucuronidation: high affinity substrates for UGT. Drug Metab. Rev., Suppl. 1, 2011.
2010
  1. Koprowska J, Skwarska A, Augustin E, Konopa J. Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells. Acta Biochim. Polonica, 57(4), Suppl.1, p. 63, 2010.
  2. Augustin E, Skwarska A, Koprowska J, Pelikant I, Konopa J. Antitumor triazoloacridinone C-1305 as a potent FLT3 tyrosine kinase inhibitor in human acute myeloid leukemia (AML) cells. Eur. J Cancer, 8 (7), p. 113, 2010.
  3. Skwarska A, Augustin E, Sobiesiak S, Koprowska J, Konopa J. Reduction of FLT3 tyrosine kinase phosphorylation and down-regulation of Survivin contribute to the activity of imidazoacridinone C-1311 against mutant FLT3-expressing leukemia cells. Eur. J Cancer, 8 (7), p. 185,  2010.
  4. Pawłowska M, Augustin E, Wolf C.R., Mazerska Z. The increased level of cytochrome P450 isoenzyme CYP3A4 affects the cellular response in CHO cells upon antitumor imidazoacridinone C-1311 treatment – Acta Biochim. Polonica, 57 (4), Suppl.1, p. 67, 2010.
  5. Potęga A, Fedejko B, Jóźwiak P, Smoliński T, Konopa J, Mazerska Z. Contribution of UDP-glucuronyltransferases, (UGTs) in metabolism of acridinone antitumor agents, C-1311 and C-1305 and their less active structural analogues, C-1330 and C-1299. Abstracts of 35th FEBS Congress, Gothenburg, 23-26 June, FEBS J, 277, Suppl.1, p. 294, 2010.
  6. Niemira M, Mazerska Z. The antitumor derivatives, C-1305 and C-1748 were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells. Abstracts of 36th FEBS Congress, Gothenburg, 23-26 June, FEBS J, 277, Suppl.1, p. 119, 2010.
2009
  1. Niemira M, Mazerska Z. The antitumor derivatives, C-1305 and C-1748 were different in effects on CYP3A4 expression and catalytic activity in HepG2 cells. Abstracts of 36th FEBS Congress, Gothenburg, 23-26 June, FEBS J, 277, Suppl.1, p. 119, 2010.
  2. Niemira M, Wiśniewska A, Konopa J, Mazerska Z. Metabolism of antitumor 9-amino-1-nitroacridine derivatives in HepG2 cells and its influence on cytochrome P450 enzymes. FEBS J, 276, Suppl 1, p. 379 ,2009.
  3. Koprowska J, Augustin E, Nowak-Ziatyk D, Konopa J. Mitotic catastrophe followed by necrosis versus pro-survival autophagy – two opposite cellular effects trigged upon C-1311 treatment in MCF7 cells. Acta Biochim. Polonica, 56 (2), Suppl.1, p. 60, 2009.
  4. Nowak-Ziatyk D, Augustin E, Konopa J. The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748. Acta Biochim. Polonica, 56 (2), Suppl.1, p. 60, 2009.
  5. Pawłowska M, Augustin E, Friedberg T, Mazerska Z. Analysis of cellular response induced by imidazoacridinone derivative C-1311 in Chinese hamster ovary carcinoma cells CHO with various expression level of cytochrome P450 reductase – Acta Biochim. Polonica, 56 (3), Suppl.1, p. 70, 2009.
  6. Mazerska Z. Specific metabolism of antitumor agents with cytochrome P450 isoenzymes, Abstracts of Joint Meeting in Medicinal Chemistry, Budapest, June 24-27, p.41 (invited lecture), 2009.
2008
  1. Wiśniewska A, Koprowska J, Niemira M, Augustin E, Konopa J, Mazerska Z. Metabolism of antitumor 9-amino-1-nitroacridine derivative C-1748 (Capridine beta) in HepG2 tumor cells. Drug Metab. Rev, 40 (1), p. 22, 2008.
  2. Augustin E, Koprowska J, Demusiak M, Konopa J. Morphological and cellular alternations of HepG2 cells overexpressing CYP3A4 after treatment with antitumor imidazoacridinone derivative C-1311. Folia Histochem. et Cytobiol., 46 (2), p. 45, 2008.
  3. Koprowska J, Augustin E, Nowak-Ziatyk D, Konopa J. Antitumor imidazoacridinone derivative C-1311 induces cell cycle arrest and cellular senescence-like phenotypic changes in human non-small lung A549 cancer cells. Acta Biochim. Polonica, 55 (3), p. 135, 2008.
  4. Nowak-Ziatyk D, Augustin E, Skwarska A, Koprowska J, Konopa J. 4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status. Acta Biochim. Polonica, 55 (3), p. 134, 2008.
  5. Potęga A, Ronseau S, Konopa J, Henderson C, Wolf CR, Mazerska Z. The role of hepatic cytochrome P450 enzymes in metabolism of imidazoacridinone antitumor agent, C-1311 (SymadexTM): Studies with hepatic NADPH:Cytochrome P450 Reductase null mice, Drug Metab. Rev, 40, Suppl.1, p.90, 2008.
2007
  1. Augustin E, Asiesiukiewicz M, Koprowska J, Konopa J. The cellular response of human hepatoma cells with different expression of cytochrome P450 isoenzymes to treatment with acridine derivatives. Acta Biochim. Polonica, 54  (4), p. 148, 2007.
  2. Augustin E, Asiesiukiewicz M, Konopa J. The cellular response of human hepatoma cells with different expression of CYP3A4 isoenzyme to treatment with triazoloacridinone derivative C-1305. Acta Biochim. Polonica, 54 (5), p. 25, 2007.
  3. Nowak D, Augustin E, Konopa J. The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status. Acta Biochim. Polonica, 54 (4), p. 154, 2007.
  4. Koprowska J, Augustin E, Konopa J. Effects on cell cycle distribution and induction of apoptosis of human breast carcinoma MCF-7 cells by imidazoacridinone C-1311. Acta Biochim. Polonica, 54 (4), p. 152, 2007.
  5. Wiśniewska A, Chrapkowska A, Konopa J, Mazerska Z. Selectivity in CYP mediated metabolism of antitumor 9-amino-1-nitroacridine derivative, C-1748 (Capridine-beta), an agent under Phase I clinical trials, Books of Abstracts, 15th International Conference on Cytochromes P450, Bled, Slovenia, p.190, June 2007.
  6. Chrapkowska A, Wiśniewska A, Konopa J, Mazerska Z. Mechanism-based selective inactivation of human CYP3A4 by antitumor imidazoacridinone agent, C-1311 (Symadexâ), Books of Abstracts, 15th International Conference on Cytochromes P450, Bled, Slovenia, p.213, June 2007.
2006
  1. Skwarska A, Augustin E, Konopa J. Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status. 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Eur. J Cancer 4, No.12 p. 148, 2006.
  2. Moś-Rompa A, Augustin E, Konopa J. Potent antitumor 4-methyl-1-nitroacridine C-1748 induces apoptosis only in part of colon cells. American Association for Cancer Research, 97th Annual Meeting, Proc. Amer. Assoc. Cancer Res., 47, p. 903, 2006.
  3. Nowak D, Augustin E, Konopa J. Oxidative stress induced by 4-methyl-1-nitroacridine derivative C-1748 (Capridine beta) in human colon cancer cells. Acta Biochim. Polonica, 53 (1), p. 92, 2006.