MSc/BEng STUDIES

Topics of MSc studies carried out in our laboratory:
  • Synthesis of new anticancer acridine and acridone derivatives.
  • Metabolism of anticancer compounds in the presence of microsomal enzymes from liver and selected recombinant enzymes. Determining the structure of metabolites.
  • Effect of overexpression of cytochrome P450 isoenzymes on type of biological response induced by acridine and acridinone derivatives in tumor cells cells.
  • Effect of FLT3 kinase inhibition on type of cellular response in myeloblastic leukemia cells exposed to antitumor acridines.
  • Preclinical studies on the effect of imidazoacridinone C-1311 on the activity of receptor tyrosine kinase FLT3 in human AML.
Topics of BEng studies currently carried out in our laboratory:
  • Tyrosine kinase inhibitors in anticancer therapy.
  • The role of Hsp proteins in apoptosis.
  • Application of flow cytometry in studies of cell death induced by cytotoxic compounds.
  • Cancer stem cells.
  • Factors affecting tumor angiogenesis.
  • Aged antitumor therapeutics in new applications.
  • Antitumor agents directed to specific differences in metabolic pathways between normal and tumor cells (tissue).
  • Procedure for the evaluation of metabolic pathways of xenobiotics in animals. Pharmacodynamic and pharmacokinetics analysis.