Laboratory of chemistry and biochemistry of anticancer drugs

Topics of PhD studies currently carried out in our laboratory:

In vitro metabolic transformations responsible for activation and detoxication of antitumor derivatives of imidazo- and triazoloacridinone.

Effect of antitumor acridine and acridinone derivatives on the level, enzymatic activity and expression of enzymes metabolising anticancer drugs.

Effect of expression of metabolising enzymes on cellular response following treatment with imidazoacridinone derivatives.

Effect of antitumor imidazoacridinone C-1311 on cell cycle and type of cellular response in non-small lung cancer A549 and breast cancer MCF-7 cells.

Effects of 4 methyl-1-nitroacridine C-1748 on induction of oxidative stress, apoptosis, mitotic catastrophe, autophagy and senescence in tumor cells.




	MAIN PAGE GROUP RESEARCH PROFILE SELECTED PAPERS SELECTED CONFERENCE REPORTS GRANTS SCIENTIFIC COOPERATION OFFER PhD STUDIES MSc/BEng STUDIES EDUCATION LABORATORY wersja polska		PhD STUDIES Topics of PhD studies currently carried out in our laboratory: In vitro metabolic transformations responsible for activation and detoxication of antitumor derivatives of imidazo- and triazoloacridinone. Effect of antitumor acridine and acridinone derivatives on the level, enzymatic activity and expression of enzymes metabolising anticancer drugs. Effect of expression of metabolising enzymes on cellular response following treatment with imidazoacridinone derivatives. Effect of antitumor imidazoacridinone C-1311 on cell cycle and type of cellular response in non-small lung cancer A549 and breast cancer MCF-7 cells. Effects of 4 methyl-1-nitroacridine C-1748 on induction of oxidative stress, apoptosis, mitotic catastrophe, autophagy and senescence in tumor cells.