Laboratory of chemistry and biochemistry of anticancer drugs

Synthesis of new acridine derivatives and testing their cytotoxic activity against selected cancer cell lines.
Studies of the effect of anticancer agents on cell cycle progression, cell death and cellular senescence.
Investigations of novel inhibitors of receptor tyrosine kinase FLT3.
Studies on the role of activation and detoxification metabolism in the mechanisms of action and biological outcome of anticancer agents. Investigations of transformation pathways with in vitro model systems and in cancer cells. Identification of metabolites.
The influence of selected anticancer compounds on the level, enzymatic activity and gene expression of drug metabolizing enzymes, in terms of drug-drug interactions predicted for antitumor therapy.
Modulation of the type of cellular response induced by anticancer agents in tumor cells characterized by various expression of metabolizing enzymes: P450, FMO and UGT families.
Electrochemical analysis of oxidation-reduction reactions of anticancer agents and their interactions with DNA. Model investigations.




	MAIN PAGE GROUP RESEARCH PROFILE SELECTED PAPERS SELECTED CONFERENCE REPORTS GRANTS SCIENTIFIC COOPERATION OFFER PhD STUDIES MSc/BEng STUDIES EDUCATION LABORATORY wersja polska		RESEARCH PROFILE Synthesis of new acridine derivatives and testing their cytotoxic activity against selected cancer cell lines. Studies of the effect of anticancer agents on cell cycle progression, cell death and cellular senescence. Investigations of novel inhibitors of receptor tyrosine kinase FLT3. Studies on the role of activation and detoxification metabolism in the mechanisms of action and biological outcome of anticancer agents. Investigations of transformation pathways with in vitro model systems and in cancer cells. Identification of metabolites. The influence of selected anticancer compounds on the level, enzymatic activity and gene expression of drug metabolizing enzymes, in terms of drug-drug interactions predicted for antitumor therapy. Modulation of the type of cellular response induced by anticancer agents in tumor cells characterized by various expression of metabolizing enzymes: P450, FMO and UGT families. Electrochemical analysis of oxidation-reduction reactions of anticancer agents and their interactions with DNA. Model investigations.